Novel anucleated cells for drug delivery and methods of use thereof
Methods for producing megakaryoctyres and platelets derived from inducible pluripotent stem cells are provided. Such megakaryocytes or platelets can be genetically modified to comprise a nucleic acid molecule encoding a therapeutic agent. The present disclosure further provides methods and compositi...
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| Format: | Patent |
| Sprache: | eng |
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| Zusammenfassung: | Methods for producing megakaryoctyres and platelets derived from inducible pluripotent stem cells are provided. Such megakaryocytes or platelets can be genetically modified to comprise a nucleic acid molecule encoding a therapeutic agent. The present disclosure further provides methods and compositions for loading a platelet or a megakaryocyte with a therapeutic agent and for genetically modifying a platelet or a megakaryocyte to express an agent. |
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