Pharmaceutical composition containing double-stranded ribonucleic acid inhibiting expression of complement C5

Disclosed is a pharmaceutical composition containing a lipid complex, wherein the lipid complex includes a double-stranded ribonucleic acid having a sense chain comprising a nucleotide sequence represented by SEQ ID NO: 145, and an antisense chain comprising a nucleotide sequence represented by SEQ...

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Bibliographische Detailangaben
Hauptverfasser:	SUZUKI, Yuta, TAKEMOTO, Seiji, ARASE, Shuntaro
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Disclosed is a pharmaceutical composition containing a lipid complex, wherein the lipid complex includes a double-stranded ribonucleic acid having a sense chain comprising a nucleotide sequence represented by SEQ ID NO: 145, and an antisense chain comprising a nucleotide sequence represented by SEQ ID NO: 146, and the pH of a lipid complex solution is 5.0 or less or 7.5 or more.