Stable and highly concentrated formulation of the antibody nimotuzumab

The present invention relates to the fields of biotechnology and medicine and describes high-concentration pharmaceutical formulations comprising the humanised monoclonal antibody nimotuzumab in a concentration range between 50 and 200 mg/mL. The low viscosity values of these solutions enable them t...

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Bibliographische Detailangaben
Hauptverfasser:	FERNÁNDEZ SÁEZ, Olga Lidea, HERNÁNDEZ TERRERO, Yaiko Saddan, CASTILLO VITLOCH, Adolfo, CEDEÑO ARIAS, Mercedes, BOGGIANO AYO, Tammy, LEÓN MONZÓN, Kalet, RASHIDA DE LA LUZ HERNÁNDEZ, Kathya, SANTO TOMÁS POMPA, Julio Felipe
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to the fields of biotechnology and medicine and describes high-concentration pharmaceutical formulations comprising the humanised monoclonal antibody nimotuzumab in a concentration range between 50 and 200 mg/mL. The low viscosity values of these solutions enable them to be used subcutaneously or intramuscularly in cancer treatments. These formulations are stable in both liquid and freeze-dried forms.