Compound as cyclin-dependent kinase 9 inhibitor and use thereof
Disclosed is a compound as shown in formula (I) or a pharmaceutically acceptable salt, a stereoisomer, an isotope derivative or a prodrug thereof. The compound has an excellent activity as a cyclin-dependent kinase 9 (CDK9) inhibitor for treating hyperprliferative diseases. The experimental research...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | AN, Hui WANG, Jia ZHANG, Yan MU, Yongzhao GAO, Na WANG, Zhenyu GUO, Jianqiao ZHANG, Chaozai |
| description | Disclosed is a compound as shown in formula (I) or a pharmaceutically acceptable salt, a stereoisomer, an isotope derivative or a prodrug thereof. The compound has an excellent activity as a cyclin-dependent kinase 9 (CDK9) inhibitor for treating hyperprliferative diseases. The experimental research on in vitro inhibition of cell proliferation and in vivo suppression of tumors shows that such compounds have a relatively strong inhibitory effect on MV4;11 cells and in vivo tumor models, and have a good selectivity and a low toxicity and few side effects, thereby possessing a good clinical value as novel anti-tumor drugs. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_AU2020401999BB2</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>AU2020401999BB2</sourcerecordid><originalsourceid>FETCH-epo_espacenet_AU2020401999BB23</originalsourceid><addsrcrecordid>eNrjZLB3zs8tyC_NS1FILFZIrkzOyczTTUktSM1LSc0rUcjOzEssTlWwVMjMy8hMyizJL1JIBCotBYqVZKQWpean8TCwpiXmFKfyQmluBhU31xBnD93Ugvz41OKCxOTUvNSSeMdQIwMjAxMDQ0tLSycnI2MilQEAjBEx8A</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>Compound as cyclin-dependent kinase 9 inhibitor and use thereof</title><source>esp@cenet</source><creator>AN, Hui ; WANG, Jia ; ZHANG, Yan ; MU, Yongzhao ; GAO, Na ; WANG, Zhenyu ; GUO, Jianqiao ; ZHANG, Chaozai</creator><creatorcontrib>AN, Hui ; WANG, Jia ; ZHANG, Yan ; MU, Yongzhao ; GAO, Na ; WANG, Zhenyu ; GUO, Jianqiao ; ZHANG, Chaozai</creatorcontrib><description>Disclosed is a compound as shown in formula (I) or a pharmaceutically acceptable salt, a stereoisomer, an isotope derivative or a prodrug thereof. The compound has an excellent activity as a cyclin-dependent kinase 9 (CDK9) inhibitor for treating hyperprliferative diseases. The experimental research on in vitro inhibition of cell proliferation and in vivo suppression of tumors shows that such compounds have a relatively strong inhibitory effect on MV4;11 cells and in vivo tumor models, and have a good selectivity and a low toxicity and few side effects, thereby possessing a good clinical value as novel anti-tumor drugs.</description><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2024</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240118&DB=EPODOC&CC=AU&NR=2020401999B2$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20240118&DB=EPODOC&CC=AU&NR=2020401999B2$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>AN, Hui</creatorcontrib><creatorcontrib>WANG, Jia</creatorcontrib><creatorcontrib>ZHANG, Yan</creatorcontrib><creatorcontrib>MU, Yongzhao</creatorcontrib><creatorcontrib>GAO, Na</creatorcontrib><creatorcontrib>WANG, Zhenyu</creatorcontrib><creatorcontrib>GUO, Jianqiao</creatorcontrib><creatorcontrib>ZHANG, Chaozai</creatorcontrib><title>Compound as cyclin-dependent kinase 9 inhibitor and use thereof</title><description>Disclosed is a compound as shown in formula (I) or a pharmaceutically acceptable salt, a stereoisomer, an isotope derivative or a prodrug thereof. The compound has an excellent activity as a cyclin-dependent kinase 9 (CDK9) inhibitor for treating hyperprliferative diseases. The experimental research on in vitro inhibition of cell proliferation and in vivo suppression of tumors shows that such compounds have a relatively strong inhibitory effect on MV4;11 cells and in vivo tumor models, and have a good selectivity and a low toxicity and few side effects, thereby possessing a good clinical value as novel anti-tumor drugs.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLB3zs8tyC_NS1FILFZIrkzOyczTTUktSM1LSc0rUcjOzEssTlWwVMjMy8hMyizJL1JIBCotBYqVZKQWpean8TCwpiXmFKfyQmluBhU31xBnD93Ugvz41OKCxOTUvNSSeMdQIwMjAxMDQ0tLSycnI2MilQEAjBEx8A</recordid><startdate>20240118</startdate><enddate>20240118</enddate><creator>AN, Hui</creator><creator>WANG, Jia</creator><creator>ZHANG, Yan</creator><creator>MU, Yongzhao</creator><creator>GAO, Na</creator><creator>WANG, Zhenyu</creator><creator>GUO, Jianqiao</creator><creator>ZHANG, Chaozai</creator><scope>EVB</scope></search><sort><creationdate>20240118</creationdate><title>Compound as cyclin-dependent kinase 9 inhibitor and use thereof</title><author>AN, Hui ; WANG, Jia ; ZHANG, Yan ; MU, Yongzhao ; GAO, Na ; WANG, Zhenyu ; GUO, Jianqiao ; ZHANG, Chaozai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_AU2020401999BB23</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>2024</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>AN, Hui</creatorcontrib><creatorcontrib>WANG, Jia</creatorcontrib><creatorcontrib>ZHANG, Yan</creatorcontrib><creatorcontrib>MU, Yongzhao</creatorcontrib><creatorcontrib>GAO, Na</creatorcontrib><creatorcontrib>WANG, Zhenyu</creatorcontrib><creatorcontrib>GUO, Jianqiao</creatorcontrib><creatorcontrib>ZHANG, Chaozai</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>AN, Hui</au><au>WANG, Jia</au><au>ZHANG, Yan</au><au>MU, Yongzhao</au><au>GAO, Na</au><au>WANG, Zhenyu</au><au>GUO, Jianqiao</au><au>ZHANG, Chaozai</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Compound as cyclin-dependent kinase 9 inhibitor and use thereof</title><date>2024-01-18</date><risdate>2024</risdate><abstract>Disclosed is a compound as shown in formula (I) or a pharmaceutically acceptable salt, a stereoisomer, an isotope derivative or a prodrug thereof. The compound has an excellent activity as a cyclin-dependent kinase 9 (CDK9) inhibitor for treating hyperprliferative diseases. The experimental research on in vitro inhibition of cell proliferation and in vivo suppression of tumors shows that such compounds have a relatively strong inhibitory effect on MV4;11 cells and in vivo tumor models, and have a good selectivity and a low toxicity and few side effects, thereby possessing a good clinical value as novel anti-tumor drugs.</abstract><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_AU2020401999BB2 |
| source | esp@cenet |
| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Compound as cyclin-dependent kinase 9 inhibitor and use thereof |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T08%3A10%3A46IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=AN,%20Hui&rft.date=2024-01-18&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EAU2020401999BB2%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |