Compound as cyclin-dependent kinase 9 inhibitor and use thereof

Disclosed is a compound as shown in formula (I) or a pharmaceutically acceptable salt, a stereoisomer, an isotope derivative or a prodrug thereof. The compound has an excellent activity as a cyclin-dependent kinase 9 (CDK9) inhibitor for treating hyperprliferative diseases. The experimental research...

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Hauptverfasser: AN, Hui, WANG, Jia, ZHANG, Yan, MU, Yongzhao, GAO, Na, WANG, Zhenyu, GUO, Jianqiao, ZHANG, Chaozai
Format: Patent
Sprache:eng
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Zusammenfassung:Disclosed is a compound as shown in formula (I) or a pharmaceutically acceptable salt, a stereoisomer, an isotope derivative or a prodrug thereof. The compound has an excellent activity as a cyclin-dependent kinase 9 (CDK9) inhibitor for treating hyperprliferative diseases. The experimental research on in vitro inhibition of cell proliferation and in vivo suppression of tumors shows that such compounds have a relatively strong inhibitory effect on MV4;11 cells and in vivo tumor models, and have a good selectivity and a low toxicity and few side effects, thereby possessing a good clinical value as novel anti-tumor drugs.