AZA-quinoline compounds and uses thereof

Provided aza-quinoline compounds of Formula (I), pharmaceutical compositions comprising such compounds; and the use of such compounds for treating a disease or condition mediated by Enhancer of Zeste Homolog 2 (EZH2), Polycomb Repressive Complex 2 (PRC2), or a combination thereof.

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Hauptverfasser: ZHANG, Ji Yue (Jeff), ZHAO, Kehao, LI, Ling, LIU, Kevin Kun Chin, DAI, Xuan, MI, Yuan, YAN, Xiaoxia, PAPILLON, Julien, YU, Zhengtian, MAK, Sing Yeung Frankie, DORE, Michael, GU, Xiang-Ju Justin, OYANG, Counde, QI, Wei (Vicky)
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creator ZHANG, Ji Yue (Jeff)
ZHAO, Kehao
LI, Ling
LIU, Kevin Kun Chin
DAI, Xuan
MI, Yuan
YAN, Xiaoxia
PAPILLON, Julien
YU, Zhengtian
MAK, Sing Yeung Frankie
DORE, Michael
GU, Xiang-Ju Justin
OYANG, Counde
QI, Wei (Vicky)
description Provided aza-quinoline compounds of Formula (I), pharmaceutical compositions comprising such compounds; and the use of such compounds for treating a disease or condition mediated by Enhancer of Zeste Homolog 2 (EZH2), Polycomb Repressive Complex 2 (PRC2), or a combination thereof.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title AZA-quinoline compounds and uses thereof
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