Methods of treating breast cancer with tetrahydronaphthalene derivatives as estrogen receptor degraders

The present application relates to treating and/or preventing breast cancer, including locally advanced or metastatic, ER+, HER2- breast cancer, in a subject in need of treatment, comprising administering a compound of Formula (I), (I), or a pharmaceutically acceptable salt, enantiomer, stereoisomer...

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Bibliographische Detailangaben
Hauptverfasser:	HASKELL III, Royal J, CHEN, Xin, FLANAGAN, John, MOORE, Marcia Dougan, QIAN, Yimin, GOUGH, Sheryl Maxine, WANG, Jing, CREW, Andrew P, TAYLOR, Ian Charles Anthony
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present application relates to treating and/or preventing breast cancer, including locally advanced or metastatic, ER+, HER2- breast cancer, in a subject in need of treatment, comprising administering a compound of Formula (I), (I), or a pharmaceutically acceptable salt, enantiomer, stereoisomer, solvate, polymorph, isotopic derivative, or prodrug thereof, wherein R