Pretomanid compositions

Described is an oral pharmaceutical composition including a granulate including a pharmaceutically effective amount of pretomanid or pharmaceutically acceptable solvate thereof. Such granulate may have a bulk density in a range of about 0.3 to 0.8 g/mL and/or a particle size distribution such that no more than about 30 wt.% of the granulate is retained on an ASTM #60 (250µm) sieve. In particular, the composition may provide that at least 40 wt.% of the pretomanid (e.g., at least 60 wt.%) is dissolved within 20 minutes as measured in a USP-II Apparatus at 37± 2° C in 0.5% hexadecyltrimethylammonium bromide (HDTMA) in 0.1N HCl.