Modeling TDP-43 proteinopathy

Modeling TDP-43 proteinopathy

Described herein is the discovery that neither the nuclear localization signal (NLS) nor the prion-like domain (PLD) of TDP-43 is necessary for embryonic stem cell culture and differentiation into motor neurons

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Bibliographische Detailangaben
Hauptverfasser: SHARMA-KANNING, Aarti, ZAMBROWICZ, Brian, FRENDEWEY, David
Format: Patent
Sprache:eng
Schlagworte:
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BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
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MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:Described herein is the discovery that neither the nuclear localization signal (NLS) nor the prion-like domain (PLD) of TDP-43 is necessary for embryonic stem cell culture and differentiation into motor neurons