Recombinant oncolytic virus, preparation method therefor, use thereof and medicine thereof

Provided are a recombinant oncolytic virus, a preparation method therefor, the use thereof and a medicine thereof, wherein the genome sequence of the recombinant oncolytic virus includes the following exogenous elements: (1) a first expression cassette containing a first promoter and a first interfe...

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1. Verfasser:	WU, Zetang
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	Provided are a recombinant oncolytic virus, a preparation method therefor, the use thereof and a medicine thereof, wherein the genome sequence of the recombinant oncolytic virus includes the following exogenous elements: (1) a first expression cassette containing a first promoter and a first interfering RNA expression sequence; (2) a target sequence; and (3) a second expression cassette. The reproduction or replication of the recombinant oncolytic virus is regulated and controlled by exogenous elements inserted into the genome sequence thereof; by means of the regulation and control by the exogenous elements, the recombinant oncolytic virus can be selectively reproduced or replicated in different types of cells, and thus, second cells, that is, target cells (such as tumor cells), can be selectively killed, and first cells, that is, non-target cells (such as normal cells), are not damaged.