Translocation control elements, reporter codes, and further means for translocation control for use in nanopore sequencing

Translocation control elements, reporter codes, and further means for translocation control for use in nanopore sequencing

Phosphoramidate-based monomers are provided for use in the synthesis of expandable polymers for nanopore-based sensing. Such monomers comprising a reporter construct that contain a first reporter code, a symmetrical chemical brancher bearing a translocation control element, and a second reporter cod...

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Bibliographische Detailangaben
Hauptverfasser: BANASIK, Brent, LOPEZ, Matthew, MACHACEK, Cara, CECH, Cynthia, O'CONNELL, Dylan, JACOBS, Aaron, NABAVI, Melud, TABONE, John, VELLUCCI, Jessica, GOODMAN, Drew, CHANDRASEKAR, Jagadeeswaran, MERRILL, Lacey, KRITZER, Svetlana, KOKORIS, Mark Stamatios
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
DERIVATIVES THEREOF
HETEROCYCLIC COMPOUNDS
METALLURGY
NUCLEIC ACIDS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC CHEMISTRY
SUGARS
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Beschreibung
Zusammenfassung:Phosphoramidate-based monomers are provided for use in the synthesis of expandable polymers for nanopore-based sensing. Such monomers comprising a reporter construct that contain a first reporter code, a symmetrical chemical brancher bearing a translocation control element, and a second reporter code, wherein the ends of the reporter construct are attached to phosphoramidate-nucleoside. Related methods and products are also provided.