Compositions and methods of using the same for treatment of neurodegenerative and mitochondrial disease

Compositions and methods of using the same for treatment of neurodegenerative and mitochondrial disease

The present disclosure is directed to nitrogen-containing heteroaryl analogs, methods of making nitrogen-containing analogs, and methods of treating disorders associated with PINK1 kinase activity including, but not limited to, neurodegenerative diseases, mitochondrial diseases, fibrosis, and/or car...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: HERTZ, Nicholas Thomas, DEVITA, Robert, CHIN, Randall Marcelo, BARTHOLOMEUS, Johan, JOHNSTONE, Shawn, DE ROULET, Daniel
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:The present disclosure is directed to nitrogen-containing heteroaryl analogs, methods of making nitrogen-containing analogs, and methods of treating disorders associated with PINK1 kinase activity including, but not limited to, neurodegenerative diseases, mitochondrial diseases, fibrosis, and/or cardiomyopathy using these analogs. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.