Integrated and continuous recombinant protein manufacturing

Integrated and continuous recombinant protein manufacturing

Integrated systems and methods for the manufacturing of recombinant proteins in mammalian cells are provided. The systems and methods include a single-use bioreactor (SUB), a tangential flow filtration system, a column chromatography skid, a tankless hold, a virus inactivation plug flow reactor, and...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: COFFMAN, Jonathan, KOTTMEIER, Robert E, FIADEIRO, Marcus Andre, OROZCO, Raquel, FAHRNER, Robert Lee, SALM, Jeffrey Richard, GODFREY, Scott A, MCLAUGHLIN, Joseph K
Format: Patent
Sprache:eng
Schlagworte:
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:Integrated systems and methods for the manufacturing of recombinant proteins in mammalian cells are provided. The systems and methods include a single-use bioreactor (SUB), a tangential flow filtration system, a column chromatography skid, a tankless hold, a virus inactivation plug flow reactor, and pumps.