Heteroaryl derivative, method for producing same, and pharmaceutical composition comprising same as effective component

Heteroaryl derivative, method for producing same, and pharmaceutical composition comprising same as effective component

The present invention relates to a 6-(isooxazolidin-2-yl)-N-phenylpyrimidin-4-amine derivative, and a pharmaceutical composition for preventing or treating cancer comprising the compound as an effective component. The compound exhibits high inhibitory activity against an epidermal growth factor rece...

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Bibliographische Detailangaben
Hauptverfasser: SEOK, Ji Yoon, KO, Yi Kyung, CHOI, Hwan Geun, KIM, Da Eun, KIM, Seung Su, SON, Jung Beom, KANG, Se In, HWANG, Dong Keun, KANG, Ju Hee, KIM, Nam Doo, RYU, Min Seok, HAN, Ah Reum, KO, Eun Hwa, KIM, Hwan, LEE, Youn Ho, LEE, Sun Hwa
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:The present invention relates to a 6-(isooxazolidin-2-yl)-N-phenylpyrimidin-4-amine derivative, and a pharmaceutical composition for preventing or treating cancer comprising the compound as an effective component. The compound exhibits high inhibitory activity against an epidermal growth factor receptor (EGFR) variant, or wild-type or variants of one or more of ERBB2 and ERBB4, and thus may be usefully used in the treatment of cancers in which same are expressed. In particular, the compound exhibits excellent inhibitory activity on proliferation of lung cancer cell lines, and thus can be usefully used in the treatment of lung cancer.