Antibody-drug conjugates including antibody against human DLK1, and use thereof

The present invention relates to: novel antibody-drug conjugates (ADC) targeting DLK1; active metabolites of the ADCs; a method for producing the ADCs; a use of the ADCs for treating and/or preventing diseases; and a use of the ADCs for producing medicaments for treating and/or preventing diseases,...

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Bibliographische Detailangaben
Hauptverfasser:	KIM, Sung Min, KIM, Hyoung Rae, YOON, Sunha, PARK, Yun-Hee, PARK, Bum-Chan, PARK, Jae Eun, LEE, Chang Sun, BAEK, Juyuel, PARK, Young Woo, CHOI, Min Ji, KIM, Yong Zu, LEE, Sang Pil, JANG, Tae Ik, CHAE, Jeiwook, SHIN, Ji-young, PARK, Chang Sik, LEE, Kun Jung, LEE, Ju Young, CHOI, Yunseon, LEE, Hyeun Joung, LEE, Jisu, SONG, Ho Young
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to: novel antibody-drug conjugates (ADC) targeting DLK1; active metabolites of the ADCs; a method for producing the ADCs; a use of the ADCs for treating and/or preventing diseases; and a use of the ADCs for producing medicaments for treating and/or preventing diseases, more specifically, hyperproliferative and/or angiogenic diseases such as cancer. More particularly, the present invention relates to an antibody-drug conjugate comprising an antibody binding to DLK1 or an antigen-binding fragment thereof, and to a pharmaceutical composition including same.