Modulators of cystic fibrosis transmembrane conductance regulator

The present invention features a compound of formula (I): W OZ, x z' (R1)n A B (R2)p (Y)0 C (R3)q (1) or a pharmaceutically acceptable salt thereof, where R 1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The presen...

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Bibliographische Detailangaben
Hauptverfasser:	Gross, Raymond Stanley, Clemens, Jeremy J, Cleveland, Thomas, Binch, Hayley Marie, Uy, Johnny, Nicholls, Georgia McGaughey, Marelius, Gulin Erdogan, Termin, Andreas P, Krenitsky, Paul John, Pierre, Fabrice Jean Denis, Khatuya, Haripada, Lin, Chun-Chieh, Silina, Alina, Conroy, Erica, McCartney, Jason, Frieman, Bryan A, Coon, Timothy Richard, Bear, Brian Richard, Arumugam, Vijayalaksmi, Grootenhuis, Peter Diederik Jan, Joshi, Pramod Virupax, Zhou, Jinglan, Miller, Mark Thomas, Melillo, Vito, Anderson, Corey, Hadida-Ruah, Sara Sabina
Format:	Patent
Sprache:	eng
Schlagworte:	AGRICULTURE ANIMAL HUSBANDRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY FISHING FORESTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HUNTING HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF TRAPPING
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Beschreibung
Zusammenfassung:	The present invention features a compound of formula (I): W OZ, x z' (R1)n A B (R2)p (Y)0 C (R3)q (1) or a pharmaceutically acceptable salt thereof, where R 1, R2, R3, W, X, Y, Z, n, o, p, and q are defined herein, for the treatment of CFTR mediated diseases, such as cystic fibrosis. The present invention also features pharmaceutical compositions, method of treating, and kits thereof.