Benzoxazepin oxazolidinone compounds and methods of use

Described herein are benzoxazepin oxazolidinone compounds with phosphoinositide 5 3 kinase (PI3K) modulation activity or function having the Formula I structure: a I R2 o or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features desc...

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Bibliographische Detailangaben
Hauptverfasser:	MACLEOD, Calum, BRAUN, Marie-Gabrielle, STABEN, Steven T, HANAN, Emily, ELLIOTT, Richard, HEALD, Robert Andrew
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Described herein are benzoxazepin oxazolidinone compounds with phosphoinositide 5 3 kinase (PI3K) modulation activity or function having the Formula I structure: a I R2 o or stereoisomers, tautomers, or pharmaceutically acceptable salts thereof, and with the substituents and structural features described herein. Also described are pharmaceutical compositions and medicaments that include the Formula I compounds, as well as methods of t0 using such P13K modulators, alone and in combination with other therapeutic agents, for treating diseases or conditions that are mediated or dependent upon P13K dysregulation.