Antigen binding proteins that bind PD-L1

Antigen binding proteins that bind PD-L1

Abstract There is disclosed compositions and methods relating to or derived from anti-PD-Li antibodies. More specifically, there is disclosed fully human antibodies that bind PD-Li, PD-Li-binding fragments and derivatives of such antibodies, and PD-Li -binding 5 polypeptides comprising such fragment...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Swanson, Barbara A, Gray, John Dixon, Kaufmann, Gunnar F, Zhou, Heyue, Gastwirt, Randy
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Abstract There is disclosed compositions and methods relating to or derived from anti-PD-Li antibodies. More specifically, there is disclosed fully human antibodies that bind PD-Li, PD-Li-binding fragments and derivatives of such antibodies, and PD-Li -binding 5 polypeptides comprising such fragments. Further still, there is disclosed nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects 10 having PD-Li related disorders or conditions, including various inflammatory disorders and various cancers.