INHIBITORS OF TRYPTOPHAN DIOXYGENASES (IDO1 and TDO) AND THEIR USE IN THERAPY

INHIBITORS OF TRYPTOPHAN DIOXYGENASES (IDO1 and TDO) AND THEIR USE IN THERAPY

Abstract N-R10 Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the 5 Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR', N or N-oxide; X is CR2 , N or N-oxide; Y is CR3, N or N-oxide; Z is CR4 , N or N-oxide; and at least one of W, X,...

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Bibliographische Detailangaben
Hauptverfasser: Ching, Lai Ming, Gamage, Swarnalatha Akuratiya, Palmer, Brian Desmond
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:Abstract N-R10 Pharmaceutical compositions comprising 3-aminoisoxazolopyridine compounds of the 5 Formula I having IDO1 and/or TDO inhibitory activity are described, where W is CR', N or N-oxide; X is CR2 , N or N-oxide; Y is CR3, N or N-oxide; Z is CR4 , N or N-oxide; and at least one of W, X, Y, and Z is N or N-oxide; and R9 and RIO are as defined. Also described are methods of using such compounds in the treatment of various conditions, such as cancer.