Solid forms of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide, compositions thereof and methods of their use

Provided herein are formulations, processes, solid forms and methods of use relating to 2 (tert-butylamino)-4-((1R,3R,4R)-3- hydroxy-4-methylcydohexylamino)-pyrimidine-5-carboxamide (Compound I). In another aspect, provided herein are methods for preparing certain compounds, including Compound I as...

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Hauptverfasser: BOERSEN, Nathan Andrew, BEAUCHAMPS, Marie Georges, NAGY, Mark A, HILGRAF, Robert, MUSLEHIDDINOGLU, Jale, YONG, Kelvin Hin-yeong, KOTHARE, Mohit Atul, HUANG, Lianfeng, MAN, Hon Wah, ZHOU, Nanfei, ZOU, Daozhong, LI, Ying, FERRETTI, Antonio Christian, XU, Jean
Format: Patent
Sprache:eng
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Zusammenfassung:Provided herein are formulations, processes, solid forms and methods of use relating to 2 (tert-butylamino)-4-((1R,3R,4R)-3- hydroxy-4-methylcydohexylamino)-pyrimidine-5-carboxamide (Compound I). In another aspect, provided herein are methods for preparing certain compounds, including Compound I as described herein, as well as intermediates useful in such methods. In certain aspects, the solid forms of Compound I are useful for inhibiting a kinase in a cell expressing said kinase, for example JNK1 or JNK2. In another aspect, the solid forms of Compound I are useful for treating or preventing one or more disorders selected from interstitial pulmonary fibrosis, systemic sclerosis, scleroderma, chronic allograft nephropathy, antibody mediated rejection, or lupus.