USE OF Dvl3-DEP PEPTIDE IN PREPARATION OF MEDICAMENT FOR REPAIRING SERTOLI CELL INJURY IN TESTES

The present disclosure relates to use of a Dvl3-DEP peptide in the preparation of a medicament for repairing Sertoli cell injury in testes, and belongs to the technical field of medicine preparation. The Dvl3-DEP peptide is used in the preparation of a medicament for repairing Sertoli cell injury in testes, and the Dvl3-DEP peptide has an amino acid sequence shown in SEQ ID NO. 1. Tests prove that the overexpression of a Dvl3-DEP-coding gene significantly increases the level of cell resistance, repairs the tight junction function among Sertoli cells destructed by perfluorooctane sulphonate (PFOS) infection and enables a tight junction among Sertoli cells, and repairs the tight junction structure among Sertoli cells. Moreover, after the overexpression of the Dvl3-DEP peptide, the level of cytoskeleton protein polymerization in the cells is significantly superior to that in an empty plasmid transfection group, and is comparable to that in a positive control group, indicating that the overexpression of the Dvl3-DEP peptide repairs the cytoskeleton structure of Sertoli cells.