USE OF LamG5 PEPTIDE IN PREPARATION OF MEDICAMENT FOR REPAIRING SERTOLI CELL INJURY IN TESTES

The present disclosure provides use of a LamG5 peptide in the preparation of a medicament for repairing Sertoli cell injury in testes, and belongs to the field of biotechnology. The LamG5 peptide used in the preparation of a medicament for repairing Sertoli cell injury in testes has an amino acid sequence shown in SEQ ID NO. 1. Experiments prove that the overexpression of a LamG5-coding gene significantly increases the level of cell resistance, repairs the tight junction function among Sertoli cells destructed by perfluorooctane sulphonate (PFOS) infection and enables a tight junction among Sertoli cells, and repairs the tight junction structure among Sertoli cells. Moreover, after the overexpression of LamG5, the cytoskeleton structure distribution in the cells is significantly superior to that in an empty plasmid transfection group, and is similar to that in a blank control group, indicating that the overexpression of LamG5 repairs the cytoskeleton structure of Sertoli cells.