Pseudofab-based multispecific binding proteins

Pseudofab-based multispecific binding proteins

Binding proteins comprising a pseudoFab domain including a stabilised knockout domain and a second VH/VL that form a first functional antigen binding domain are provided. Multispecific binding proteins comprising at least one pseudoFab are also provided. Multispecific binding proteins, nucleic acids...

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Bibliographische Detailangaben
Hauptverfasser: LEUSCHNER, Wulf-Dirk, ENGEL, Karl-Christian, LANGE, Christian, BEIL, Christian, LEMOINE, Cendrine, RAO, Ercole, WEIL, Sandra, LANGER, Thomas, HOELPER, Soraya, HESSLER, Gerhard, SPINDLER, Nadja, OEZGUER BRUEDERLE, Sevim
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:Binding proteins comprising a pseudoFab domain including a stabilised knockout domain and a second VH/VL that form a first functional antigen binding domain are provided. Multispecific binding proteins comprising at least one pseudoFab are also provided. Multispecific binding proteins, nucleic acids encoding binding proteins and multispecific binding proteins, expression vectors, host cells, pharmaceutical composition and methods of treatment administering the binding proteins or multispecific binding proteins described herein are also provided.