Six-membered fused with six-membered heterocyclic compound and uses thereof serving as protein receptor kinase inhibitor

Six-membered fused with six-membered heterocyclic compound and uses thereof serving as protein receptor kinase inhibitor

Provided are a preparation and applications of a six-membered and six-membered heterocyclic compound, specifically, provided in the present invention is a compound as represented by formula I as follows, where the definitions of the groups are as described in the description. The compound has TRK ki...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: SHANG, Ke, XU, Lingling, JIANG, Lei, JIN, Xian, XU, Yuan, ZHANG, Yuxing, SHOU, Jianyong, FENG, Zhiyong, WU, Danyi, QIAO, Zhi, ZHANG, Shuyun, ZHANG, Yi
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:Provided are a preparation and applications of a six-membered and six-membered heterocyclic compound, specifically, provided in the present invention is a compound as represented by formula I as follows, where the definitions of the groups are as described in the description. The compound has TRK kinase inhibiting activity and can serve as a pharmaceutical composition for treating TRK dysfunction-related diseases. (I)