Anti-CD137 antigen-binding molecule and utilization thereof

The purpose of the present disclosure is to provide anti-CD137 antigen-binding molecules that have an effect of activating immunocytes, a cytotoxic activity or an antitumor activity and yet scarcely affect non-tumor tissues such as normal tissues and have few side effects, and a method for using the...

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Hauptverfasser:	HORI, Yuji, KADONO, Shojiro, KAWAUCHI, Hiroki, HAYASAKA, Akira, TATSUMI, Kanako, SAVORY, Nasa, KAMIKAWA, Takayuki, MIYAZAKI, Taro, SHIMIZU, Shun, IGAWA, Tomoyuki, MIMOTO, Futa, KAMIMURA, Masaki, HIRONIWA, Naoka, HASEGAWA, Masami, KAWAI, Takeaki, SAKURAI, Mika, NARITA, Yoshinori
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The purpose of the present disclosure is to provide anti-CD137 antigen-binding molecules that have an effect of activating immunocytes, a cytotoxic activity or an antitumor activity and yet scarcely affect non-tumor tissues such as normal tissues and have few side effects, and a method for using these molecules. By finding a CD137 antigen-binding molecule that shows a change in CD137-binding activity depending on various substances (for example, a low molecular compound) in a target tissue and producing the molecule, provided is an anti-CD137 antigen-binding molecule that has an effect of activating immunocytes, a cytotoxic activity or an antitumor activity and yet scarcely affects non-tumor tissues such as normal tissues and has few side effects. Also provided are a method for using the anti-CD137 antigen-binding molecule, a pharmaceutical formulation, etc. The present disclosure also provides an antigen-binding molecule showing a change in antigen-binding activity depending on a low molecular compound, a method for producing the molecule and utilization of the same.