GIP/GLP1 co-agonist compounds

The present invention relates to compounds having activity at both the human glucose-dependent insulinotropic polypeptide (GIF) and glucagon-like peptide-1 (GLP-1) receptors. The present invention also relates to compounds having an extended duration of action at each of these receptors. Furthermore...

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Bibliographische Detailangaben
Hauptverfasser:	WALLIS, James Lincoln, ABURUB, Aktham, BROWN, Robert Andrew, SLOOP, Kyle Wynn, ABRAHAM, Milata Mary, ELSAYED, Mohamed ElSayed Hamed, PATEL, Phenil Jayantilal, TRAN, Thi Thanh Huyen, QU, Hongchang, CUMMINS, Robert Chadwick, WILLARD, Francis Stafford, CABRERA, Over, DATTA-MANNAN, Amita, ALSINA-FERNANDEZ, Jorge, LAI, Xianyin, COSKUN, Tamer
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present invention relates to compounds having activity at both the human glucose-dependent insulinotropic polypeptide (GIF) and glucagon-like peptide-1 (GLP-1) receptors. The present invention also relates to compounds having an extended duration of action at each of these receptors. Furthermore, the present invention relates to compounds that may be administered orally. Compounds may be useful in the treatment of type 2 diabetes mellitus ("T2DM"). Also, the compounds may be useful in the treatment of obesity.