Compound and use thereof in synthesis of brivaracetam intermediate and crude drug

The present application provides a compound in formula III, and further provides a use of the compound in the synthesis of a Brivaracetam intermediate and a crude drug, and a synthesis method. A raw material involved in the method of the present application is low in costs and easily available; (R)-...

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Bibliographische Detailangaben
Hauptverfasser: WANG, Ruyong, WANG, Zhonghong, KANG, Xinshan, GONG, Xuan, YE, Yizhang, FENG, Yan, ZHANG, Fengsen
Format: Patent
Sprache:eng
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Beschreibung
Zusammenfassung:The present application provides a compound in formula III, and further provides a use of the compound in the synthesis of a Brivaracetam intermediate and a crude drug, and a synthesis method. A raw material involved in the method of the present application is low in costs and easily available; (R)-4-propyl-dihydrofuran-2-ketone having high optical purity can be prepared; complicated separation and purification steps are avoided; costs are reduced, and the method is more applicable to industrial production.