Prosthetic heart valve devices, prosthetic mitral valves and associated systems and methods

Prosthetic heart valve devices for percutaneous replacement ofnative heart valves and associated systems and method are disclosed herein. A prosthetic heart valve device configured in accordance with a particular embodiment of the present technology can include an anchoring member having an upstream portion configured to engage with tissue on or near the annulus of the native heart valve and to deform in a non-circular shape to conform to the tissue. The device can also include a mechanically isolated valve support coupled to the anchoring member and configured to support a prosthetic valve. The device can further include an atrial extension member extending radially outward from the upstream portion of the anchoring member and which is deformable without substantially deforming the anchoring member. In some embodiments, the upstream portion of the anchoring member and the extension member may be deformed while the valve support remains sufficiently stable. 2130,2132 2120 2112 - }170a 170a 17101 -112 4H/ Ht 170 -10, 150 140a 2109 2100 140b 13 4a113