Galenic formulations of organic compounds

Abstract The present invention relates to a solid unit oral dosage form comprising sacubitril and valsartan in a 1:1 molar ratio, preferably in the form of the so-called angiotensin receptor neprilysin inhibitor (ARNI) LCZ696, which is a complex salt hydrate of sacubitril, valsartan, 5 and sodium io...

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Bibliographische Detailangaben
Hauptverfasser: Winzenburg, Gesine, Trueby, Bernd, Bush, Christopher, Chen, Fabian, Berkhin, Masha, Ayalasomayajula, Surya Prakash
Format: Patent
Sprache:eng
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Zusammenfassung:Abstract The present invention relates to a solid unit oral dosage form comprising sacubitril and valsartan in a 1:1 molar ratio, preferably in the form of the so-called angiotensin receptor neprilysin inhibitor (ARNI) LCZ696, which is a complex salt hydrate of sacubitril, valsartan, 5 and sodium ions, appropriate for use in pediatrics or other patients where low and individual dosing is required or who encounter problems with swallowing e.g. as a result of a disease or because of age, to the manufacture of said solid dosage form and to invention embodiments relating to therapy using said dosage form.