COMPOSITIONS AND METHODS DIRECTED TO TREATING LIVER FIBROSIS

The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the COL1A1, TGF-beta, and SMAD2/3 genes, and methods of using such dsRNA compositions to inhibit expression of COL1A1, TGF-beta, and SMAD2/3. WO 2011/153323 PCT/US2O11/038889 Cl) 0f QI) ' CfJ > 0 C:~ CN...

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Bibliographische Detailangaben
Hauptverfasser:	Sehgal, Alfica, Bettencourt, Brian, Novobrantseva, Tatiana, Hinkle, Greg, Kotelianski, Victor
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA DERIVATIVES THEREOF ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the COL1A1, TGF-beta, and SMAD2/3 genes, and methods of using such dsRNA compositions to inhibit expression of COL1A1, TGF-beta, and SMAD2/3. WO 2011/153323 PCT/US2O11/038889 Cl) 0f QI) ' CfJ > 0 C:~ CN tm U, 0 -oTo m1 c >-T -T "r) "- 0 Lu - 0 VNWU-DLL0