Tablet formulation for CGRP-active compounds

Colloidal Silica (Cob-O-Sil) Cosieve Microcrystalne Celluloe(Acl) Milled dispersion Screen (optional) Mannili NaCl Powder Crocarmellse Sodum Blend/Lubdcate Coseved Cob-O-Sil/Avicel Sodium Stearyl Fumarate Compress to Tablet R"R The present invention is directed to compositions comprising an ext...

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Bibliographische Detailangaben
Hauptverfasser:	XU, Wei, IKEDA, Craig B, ALLAIN, Leonardo Resende, LUPTON, Lisa, NOFSINGER, Rebecca, FLANAGAN Jr., Francis J, XI, Hanmi, EICKHOFF, W. Mark, MAROTA, Melanie, PATEL, Paresh B, JOHNSON, Mary Ann, BROWN, Chad D
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:	Colloidal Silica (Cob-O-Sil) Cosieve Microcrystalne Celluloe(Acl) Milled dispersion Screen (optional) Mannili NaCl Powder Crocarmellse Sodum Blend/Lubdcate Coseved Cob-O-Sil/Avicel Sodium Stearyl Fumarate Compress to Tablet R"R The present invention is directed to compositions comprising an extmdate or solid solution of a compound, or a salt thereof, of Formula I (API): Formula I, wherein "Ra" is independently H or -F, in a water-soluble polymer matrix which further comprises a disintegration system allowing a tablet made therefrom to rapidly disintegrate in the environment in which the API is to be released.