Peptide nucleic acid complex having endosomal escape capacity, and use thereof

The present invention relates to: a novel-structured nucleic acid complex for enabling a bioactive nucleic acid to be introduced into a cell; a composition comprising same, for treating or diagnosing a disease; and a method for regulating the expression of a target gene using same. More specifically...

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Bibliographische Detailangaben
Hauptverfasser:	YU, Ji-Yeon, PARK, Hee Kyung, KANG, Yusun, KIM, Hye Joo, LEE, Dong In
Format:	Patent
Sprache:	eng
Schlagworte:	BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR COMPOSITIONS THEREOF CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES OF PREPARING SUCH COMPOSITIONS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE
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Beschreibung
Zusammenfassung:	The present invention relates to: a novel-structured nucleic acid complex for enabling a bioactive nucleic acid to be introduced into a cell; a composition comprising same, for treating or diagnosing a disease; and a method for regulating the expression of a target gene using same. More specifically, the present invention relates to: a nucleic acid complex containing an endosomal escape-aiding material, and having a bioactive nucleic acid complementarily bound with a carrier peptide nucleic acid; a composition comprising same, for treating or diagnosing a disease; a composition comprising same, for regulating the expression of a target gene; and a method for regulating the expression of a target gene using same. The nucleic acid complex, according to the present invention, represented by structural formula (1) and comprising the bioactive nucleic acid and the carrier peptide nucleic acid may increase the stability of the bioactive nucleic acid, reduce losses such as sedimentation due to the self-aggregation of the bioactive nucleic acid, increase efficiency in the delivery of the bioactive nucleic acid into a cell, and enable the expression of a target gene to be easily regulated. In addition, the nucleic acid complex contains the endosomal escape-aiding material, and thus is useful in enabling the nucleic acid complex to be effectively active at the cytoplasm when the nucleic acid complex has penetrated inside a cell by cellular internalization.