Crystalline forms of the CXCR7 receptor antagonist (3s,4s)-1-Cyclopropylmethyl-4-{(5-(2,4-difluoro-phenyl)-isoxazole-3-carbonyl)-amino}-piperidine-3-carboxylic acid (1-pyrimidin-2-yl-cyclopropyl)-amide

Crystalline forms of the CXCR7 receptor antagonist (3s,4s)-1-Cyclopropylmethyl-4-{(5-(2,4-difluoro-phenyl)-isoxazole-3-carbonyl)-amino}-piperidine-3-carboxylic acid (1-pyrimidin-2-yl-cyclopropyl)-amide

The application relates to crystalline forms of (3S,4S)-1- Cyclopropylmethyl-4-{[5-(2,4-difluoro-phenyl)-isoxazole-3-carbonyl]- amino}-piperidine-3-carboxylic acid (1-pyrimidin-2-yl-cyclopropyl)- amide; processes for the preparation thereof, and pharmaceutical compositions containing such crystallin...

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Bibliographische Detailangaben
Hauptverfasser: GUERRY, Philippe, VON RAUMER, Markus
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:The application relates to crystalline forms of (3S,4S)-1- Cyclopropylmethyl-4-{[5-(2,4-difluoro-phenyl)-isoxazole-3-carbonyl]- amino}-piperidine-3-carboxylic acid (1-pyrimidin-2-yl-cyclopropyl)- amide; processes for the preparation thereof, and pharmaceutical compositions containing such crystalline forms. The compound acts as CXCR7 receptor modulator and is thus useful for the treatment of cancer.