Modified AXL peptides and their use in inhibition of AXL signaling in anti-metastatic therapy

Modified AXL peptides and their use in inhibition of AXL signaling in anti-metastatic therapy

Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL, MER or Tyro3 protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL,...

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Hauptverfasser: Jones, Douglas, Cochran, Jennifer R, Hershenson, Susan, Giaccia, Amato J, Rankin, Erinn Bruno, Kariolis, Mihalis, Miao, Yu, Fuh, Katherine
Format: Patent
Sprache:eng
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CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:Compositions and methods are provided for alleviating cancer in a mammal by administering a therapeutic dose of a pharmaceutical composition that inhibits activity of AXL, MER or Tyro3 protein activity, for example by competitive or non-competitive inhibition of the binding interaction between AXL, MER or Tyro3 and its ligand GAS6.