Compositions and methods for capture of cellular targets of bioactive agents

The present invention provides compositions and methods for capture and identification of the cellular targets of a bioactive agent. In particular, provided herein are bioactive agents tethered to capture ligand, cellular targets (optionally tagged with a 5 reporter), capture proteins (optionally pr...

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Hauptverfasser: MEISENHEIMER, Poncho, OTTO, Paul, KLAUBERT, Dieter, HURST, Robin, NATH, Nidhi, KIRKLAND, Thomas, HITKO, Carolyn W, OHANA, Rachel F, URH, Marjeta, WOOD, Keith, UYEDA, Harry Tetsuo
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention provides compositions and methods for capture and identification of the cellular targets of a bioactive agent. In particular, provided herein are bioactive agents tethered to capture ligand, cellular targets (optionally tagged with a 5 reporter), capture proteins (optionally present as capture fusions), surfaces (e.g., displaying, capture ligands, capture proteins, or capture fusions), and methods of capturing and identifying the cellular targets of a bioactive agent therewith. 6569282_1 (GHMatters) P100158.AU LYNT