Methylene linked quinolinyl modulators of ROR-gamma-T

METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T Abstract The present invention comprises compounds of Formula (I). wherein: R1, R2 , R3 , R4 , R5 , R6 , R7 , R", and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder...

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Bibliographische Detailangaben
Hauptverfasser:	Leonard, Kristi A, Jones, William Moore, Fourie, Anne, Cummings, Maxwell D, Woods, Craig R, Venkatesan, Hariharan, Goldberg, Steven, Kreutter, Kevin D, Kummer, David A, Urbanski, Maud, Wang, Aihua, Xue, Xiaohua, Maharoof, Umar, Nishimura, Rachel, Edwards, James P, Barbay, Kent, Wolin, Ronald L
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:	METHYLENE LINKED QUINOLINYL MODULATORS OF ROR-GAMMA-T Abstract The present invention comprises compounds of Formula (I). wherein: R1, R2 , R3 , R4 , R5 , R6 , R7 , R", and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating RORyt activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim Ra