Methods based on the detection of RAD51 foci in tumor cells

Methods based on the detection of RAD51 foci in tumor cells

The invention provides a method allowing to determine whether a subject diagnosed with cancer is sensitive or resistant to an anti-cancer treatment, based on the level of cells with RAD51 foci in a sample containing tumor cells isolated from said subject, wherein the subject has not received at 24 h...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: O'CONNOR, Mark J, BALMAÑA GELPI, Judith, JONES, Gemma Nicole, LLOP GUEVARA, Alba, CASTROVIEJO BERMEJO, Marta, CRUZ ZAMBRANO, Cristina, SERRA ELIZALDE, Violeta
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
MEDICAL OR VETERINARY SCIENCE
PHYSICS
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
TESTING
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Beschreibung
Zusammenfassung:The invention provides a method allowing to determine whether a subject diagnosed with cancer is sensitive or resistant to an anti-cancer treatment, based on the level of cells with RAD51 foci in a sample containing tumor cells isolated from said subject, wherein the subject has not received at 24 hours prior to the isolation of the sample, a chemotherapy selected from the group consisting of AC, FEC, ECF and navelbine/epirubicin, and wherein the sample has not been treated with a method that induces DNA damage before determining the level of cells with RAD51 foci.