FC binding fragments comprising a PD-L1 antigen-binding site

FC binding fragments comprising a PD-L1 antigen-binding site

The application relates to specific binding members which bind to programmed death-ligand (PD-L1). The specific binding members preferably comprise a PD-L1antigen-binding site located in structural loops of a constant domain of the specific binding member. The specific binding members find applicati...

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Bibliographische Detailangaben
Hauptverfasser: TUNA, Mihriban, WOLLERTON VAN HORCK, Francisca, AKELE, Frederick, BADR, Fadi, FIEHLER, Ryan, PRIVEZENTZEV, Cyril, FAROUDI, Mustapha
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Zusammenfassung:The application relates to specific binding members which bind to programmed death-ligand (PD-L1). The specific binding members preferably comprise a PD-L1antigen-binding site located in structural loops of a constant domain of the specific binding member. The specific binding members find application, for example, in the treatment of cancer, as well as infectious diseases, inflammation, diseases and conditions associated with inflammation, and inflammatory diseases.