Antiproliferative compounds and methods of use thereof

Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myel...

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Bibliographische Detailangaben
Hauptverfasser:	ALEXANDER, Matthew D, TAVARES-GRECO, Paula A, CORREA, Matthew D, LOPEZ-GIRONA, Antonia, CARMICHAEL, James, NAGY, Mark A, LU, Xiaoling, HANSEN, Joshua, CATHERS, Brian E, ARTMAN III, Gerald D, BRAY, Gordon L, CARRANCIO, Soraya, PICCOTTI, Joseph R, MAN, Hon-Wah, WONG, Lilly L, PIERCE, Daniel W, HAVENS, Courtney G, NARLA, Rama K, WHITEFIELD, Brandon W, KERCHER, Timothy S, ZOU, Nanfei
Format:	Patent
Sprache:	eng
Schlagworte:	CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	Provided herein is 4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile, or an enantiomer, a mixture of enantiomers, a tautomer, or a pharmaceutically acceptable salt thereof, and methods for treating, preventing or managing multiple myeloma using such compounds. Also provided are pharmaceutical compositions comprising the compounds, and methods of use of the compositions.