Method of manufacturing bispecific antibodies, bispecific antibodies and therapeutic use of such antibodies

Method of manufacturing bispecific antibodies, bispecific antibodies and therapeutic use of such antibodies

The invention relates to bivalent bispecific monoclonal antibodies (bbmAb) or variants thereof, and methods of manufacturing such antibodies by co-expressing modified Fc- 5 mutated derivatives of two different monoclonal antibodies in mammalian cell lines.

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Graf, Christian, Jostock, Thomas, Oliver, Stephen John, Knopf, Hans-Peter, Koehler, Rolf, Kovarik, Jiri, Heitmann, Daniel, Buch, Tina, Woisetschlaeger, Maximilian, Bardroff, Michael Otto, Patel, Dhavalkumar
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
Online-Zugang:Volltext bestellen
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:The invention relates to bivalent bispecific monoclonal antibodies (bbmAb) or variants thereof, and methods of manufacturing such antibodies by co-expressing modified Fc- 5 mutated derivatives of two different monoclonal antibodies in mammalian cell lines.