Novel cell-permeable succinate compounds

C: \Interwovn\NRPortbl\DCC\RBR\18217887_l.docx-l9 12 2018 The present invention provides novel cell-permeable succinates and cell permeable precursors of succinate aimed at increasing ATP-production in mitochondria. The main 5 part of ATP produced and utilized in the eukaryotic cell originates from...

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Bibliographische Detailangaben
Hauptverfasser:	Ehinger, Karl Henrik Johannes, Moss, Steven, Elmer, Eskil, Hansson, Magnus Joakim
Format:	Patent
Sprache:	eng
Schlagworte:	ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	C: \Interwovn\NRPortbl\DCC\RBR\18217887_l.docx-l9 12 2018 The present invention provides novel cell-permeable succinates and cell permeable precursors of succinate aimed at increasing ATP-production in mitochondria. The main 5 part of ATP produced and utilized in the eukaryotic cell originates from mitochondrial oxidative phosphorylation, a process to which high-energy electrons are provided by the Kreb's cycle. Not all Kreb's cycle intermediates are readily permeable to the cellular membrane, one of them being succinate. The provision of the novel cell permeable succinates is envisaged to allow passage over the cellular membrane and thus the cell 10 permeable succinates can be used to enhance mitochondrial ATP-output.