An improved method for high level production of CRM

An improved method for high level production of CRM

The present invention provides an improved method for the production of CRM197 with high yield using engineered Corynebacterium diphtheria strain having increased copy number of CRM197 gene, wherein the method comprises growing the strain in a media free of animal derived components with one or more...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Sriraman, Rajan, Mantena, Narender Dev, Dixit, Mandar Shirish, Matur, Ramesh Venkat, Sureddi, Satyam Naidu, Chakka, Deviprasanna, Datla, Mahima, Masilamani, Balamurali
Format: Patent
Sprache:eng
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
ENZYMOLOGY
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE
METALLURGY
MICROBIOLOGY
MUTATION OR GENETIC ENGINEERING
ORGANIC CHEMISTRY
PEPTIDES
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The present invention provides an improved method for the production of CRM197 with high yield using engineered Corynebacterium diphtheria strain having increased copy number of CRM197 gene, wherein the method comprises growing the strain in a media free of animal derived components with one or more amino acids.