Pyrrolobenzodiazepine dimer precursor and ligand-linker conjugate compound thereof

The present invention relates to a pyrrolobenzodiazepine precursor and a ligand-linker conjugate compound thereof, a composition containing the same, and, in particular, a therapeutic use thereof as an anti-cancer agent. The present invention is industrially useful in that it is possible to target p...

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Hauptverfasser: Lee, Hyeun Joung, Kim, Sung Min, Oh, Jihye, Kim, Hyoung Rae, Kim, Yong Zu, Park, Yun-Hee, Chae, Jeiwook, Chung, Chul-Woong, Park, Kyung Eun, Lee, Ju Young, Oh, Yeong Soo, Lee, Su In, Baek, Juyuel, Choi, Hyo Jung, Song, Ho Young
Format: Patent
Sprache:eng
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Zusammenfassung:The present invention relates to a pyrrolobenzodiazepine precursor and a ligand-linker conjugate compound thereof, a composition containing the same, and, in particular, a therapeutic use thereof as an anti-cancer agent. The present invention is industrially useful in that it is possible to target proliferative diseases such as cancer, perform a specific treatment, maximize medicinal effects, and minimize the occurrence of side effects, since the compound itself is very stable, has excellent stability in plasma, and has advantages in terms of toxicity manifestation.