Methods of treating Crohn's disease and ulcerative colitis

The present disclosure is directed to methods for treating Crohn's disease, and in particular, to methods for inducing clinical remission and/or endoscopic improvement of Crohn's disease, using a JAK1 inhibitor. In certain embodiments, the patient is administered an induction dose of the J...

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Bibliographische Detailangaben
Hauptverfasser:	Robinson, Anne M, Nordstrom, Fredrik Lars, Enejosa, Jose Jeffrey V, Machado De Lacerda, Ana Paula, Mulhern, Mathew M, Mayer, Peter T, Jungerwirth, Steven, Borchardt, Thomas B, Jayanth, Jayanthy, Klünder, Ben, Sheikh, Ahmad Y, Marroum, Patrick J, Thakkar, Roopal B, Mohamed, Mohamed-Eslam, Othman, Ahmed, Pangan, Aileen L, Allian, Ayman D
Format:	Patent
Sprache:	eng
Schlagworte:	HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:	The present disclosure is directed to methods for treating Crohn's disease, and in particular, to methods for inducing clinical remission and/or endoscopic improvement of Crohn's disease, using a JAK1 inhibitor. In certain embodiments, the patient is administered an induction dose of the JAK1 inhibitor to induce clinical remission and/or endoscopic improvement of the Crohn's disease, followed by administration of at least one maintenance dose of the JAK1 inhibitor thereafter. In other embodiments, the present disclosure is directed to methods for treating ulcerative colitis using a JAK1 inhibitor.