Aptamer-drug conjugate and use thereof

Aptamer-drug conjugate and use thereof

The present invention relates to a cancer targeted therapeutic comprising a drug-linker-AS1411 structure, wherein the drug may be selected from monomethyl auristatin E (MMAE), monomethyl auristatin F (MMAF), cytarabine, gemcitabine, maytansine, DM1, DM4, calicheamicin and a derivative thereof, doxor...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Lee, Jung Hwan, Im, Jong Hun, Kim, Jong In
Format: Patent
Sprache:eng
Schlagworte:
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BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
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MICROBIOLOGY
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MUTATION OR GENETIC ENGINEERING
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
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Beschreibung
Zusammenfassung:The present invention relates to a cancer targeted therapeutic comprising a drug-linker-AS1411 structure, wherein the drug may be selected from monomethyl auristatin E (MMAE), monomethyl auristatin F (MMAF), cytarabine, gemcitabine, maytansine, DM1, DM4, calicheamicin and a derivative thereof, doxorubicin, duocarmycin and a derivative thereof, pyrrolobenzodiazepine (PBD), SN-38, a-amanitin, and a tubulysin analog.