PROCESS FOR PREPARING 7H-PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES AND SYNTHETIC INTERMEDIATES THEREOF

PROCESS FOR PREPARING 7H-PYRROLO[2,3-d]PYRIMIDINE DERIVATIVES AND SYNTHETIC INTERMEDIATES THEREOF

The purpose of the present invention is to provide: a method for producing a 7H-pyrrolo[2,3-d]pyrimidine derivative which is useful as a Janus kinase (JAK) inhibitory agent; an intermediate of the same; and a method for producing the intermediate. Provided is a method for producing 3-[(3S,4R)-3-meth...

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Bibliographische Detailangaben
Hauptverfasser: Takiguchi, Hiromu, Ebdrup, Soren, Watanabe, Takashi, Jensen, Kim Lebek, Vedsoe, Per, Higashi, Akinobu, Takeichi, Tsubasa, Petersen, Anders Klarskov, Inaba, Takashi, Bornholdt, Jan
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Zusammenfassung:The purpose of the present invention is to provide: a method for producing a 7H-pyrrolo[2,3-d]pyrimidine derivative which is useful as a Janus kinase (JAK) inhibitory agent; an intermediate of the same; and a method for producing the intermediate. Provided is a method for producing 3-[(3S,4R)-3-methyl-6-(7H-pyrrolo[2,3-d]pyrimidine-4-yl)-1,6-Diazaspiro[3.4]octane-1-yl]-3-oxopropanenitrile using an organic acid of (3S,4R)-1-benzyl-3-methyl-1,6-Diazaspiro[3.4]octane and a salt thereof.