Method to distinguish tumor suppressive FOXO activity from oxidative stress

Method to distinguish tumor suppressive FOXO activity from oxidative stress

The present invention relates to certain target genes of the FOXO transcription factor family, which are markers for an oxidative stress state and can be used for inferring an oxidative stress state of a FOXO transcription factor element in the body of a medical subject. The invention further relate...

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Hauptverfasser: Van Ooijen, Hendrik Jan, Velter, Rick, Verhaegh, Wilhelmus Franciscus Johannes, Van De Stolpe, Anja, Akse, Martijn Theodorus Lambert
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CHEMISTRY
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ORGANIC CHEMISTRY
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creator Van Ooijen, Hendrik Jan
Velter, Rick
Verhaegh, Wilhelmus Franciscus Johannes
Van De Stolpe, Anja
Akse, Martijn Theodorus Lambert
description The present invention relates to certain target genes of the FOXO transcription factor family, which are markers for an oxidative stress state and can be used for inferring an oxidative stress state of a FOXO transcription factor element in the body of a medical subject. The invention further relates to methods for inferring an oxidative stress state of a FOXO transcription element and for inferring the activity of the FOXO/PI3K cellular signalling pathway based on expression levels of the target genes as well as products to perform the methods.
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METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
title Method to distinguish tumor suppressive FOXO activity from oxidative stress
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