Method to distinguish tumor suppressive FOXO activity from oxidative stress

Method to distinguish tumor suppressive FOXO activity from oxidative stress

The present invention relates to certain target genes of the FOXO transcription factor family, which are markers for an oxidative stress state and can be used for inferring an oxidative stress state of a FOXO transcription factor element in the body of a medical subject. The invention further relate...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Van Ooijen, Hendrik Jan, Velter, Rick, Verhaegh, Wilhelmus Franciscus Johannes, Van De Stolpe, Anja, Akse, Martijn Theodorus Lambert
Format: Patent
Sprache:eng
Schlagworte:
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
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Beschreibung
Zusammenfassung:The present invention relates to certain target genes of the FOXO transcription factor family, which are markers for an oxidative stress state and can be used for inferring an oxidative stress state of a FOXO transcription factor element in the body of a medical subject. The invention further relates to methods for inferring an oxidative stress state of a FOXO transcription element and for inferring the activity of the FOXO/PI3K cellular signalling pathway based on expression levels of the target genes as well as products to perform the methods.