Vascular grafts, method of manufacturing thereof and articles comprising the same

Disclosed herein is a method of manufacturing a vascular graft comprising disposing cells of a first cell type on a core having a textured surface, wherein the textured surface comprises a plurality of spaced features, the spaced features being arranged in a plurality of groupings, the groupings of...

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Bibliographische Detailangaben
Hauptverfasser:	Magin, Chelsea Marie, Brennan, Anthony B
Format:	Patent
Sprache:	eng
Schlagworte:	APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OF CARBONFILAMENTS BANDAGES, DRESSINGS OR ABSORBENT PADS CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, ORSURGICAL ARTICLES CHEMICAL FEATURES IN THE MANUFACTURE OF ARTIFICIAL FILAMENTS,THREADS, FIBRES, BRISTLES OR RIBBONS DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF,TUBULAR STRUCTURES OF THE BODY, E.G. STENTS DISINFECTION, STERILISATION, OR DEODORISATION OF AIR FILTERS IMPLANTABLE INTO BLOOD VESSELS FIRST-AID KITS FOMENTATION HUMAN NECESSITIES HYGIENE MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICALARTICLES MECHANICAL METHODS OR APPARATUS IN THE MANUFACTURE OFARTIFICIAL FILAMENTS, THREADS, FIBRES, BRISTLES ORRIBBONS MEDICAL OR VETERINARY SCIENCE METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS INGENERAL NATURAL OR ARTIFICIAL THREADS OR FIBRES ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES PROSTHESES SPINNING TEXTILES TREATMENT OR PROTECTION OF EYES OR EARS
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Beschreibung
Zusammenfassung:	Disclosed herein is a method of manufacturing a vascular graft comprising disposing cells of a first cell type on a core having a textured surface, wherein the textured surface comprises a plurality of spaced features, the spaced features being arranged in a plurality of groupings, the groupings of spaced features being arranged with respect to one another so as to define a tortuous path when viewed in a first direction; growing the cells to form a primary cell-seeded construct, wherein the primary cell-seeded construct has a textured inner surface that is a negative image of the textured surface of the core; contacting the primary cell-seeded construct with a second cell type to form a secondary cell-seeded construct; and removing the core to produce the vascular graft.