Immolative cell-penetrating complexes for nucleic acid delivery

Immolative cell-penetrating complexes for nucleic acid delivery

There are provided herein, inter alia, complexes, compositions and methods for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acid, into a cell. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides an...

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Bibliographische Detailangaben
Hauptverfasser: Haabeth, Ole Audun Werner, Near, Katherine, Levy, Ronald, Wender, Paul, Vargas, Jessica R, Blake, Tim, Benner, Nancy, Waymouth, Robert M, McKinlay, Colin
Format: Patent
Sprache:eng
Schlagworte:
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Beschreibung
Zusammenfassung:There are provided herein, inter alia, complexes, compositions and methods for the delivery of therapeutic, diagnostic and imaging agents, including nucleic acid, into a cell. The complexes, compositions and methods may facilitate complexation, protection, delivery and release of oligonucleotides and polyanionic cargos into target cells, tissues, and organs both in vitro and in vivo.